What Constitutions Are Prone to Miscarriage?

February 19, 2024

Some people are prone to colds, which may be due to a deficiency of qi; some people are often depressed, which may be due to a stagnation of qi; some people experience painful periods, and yes, it may be due to a blood stasis constitution, which is also one of the causes of recurrent miscarriage. So what kind of constitution is prone to miscarriage?


1. Uterine Malformation

Women with uterine malformations (such as bicornuate uterus, uterine septum, and uterine developmental disorders) will affect embryo implantation and development, leading to miscarriage; cervical incompetence or deep cervical laceration can cause premature rupture of the fetal membrane and late miscarriage.

The first prenatal examination is particularly important because usually during the first prenatal examination, the gynecological speculum examination can be used to understand the condition of the vagina and cervix, and exclude the possibility of abnormal development of the reproductive organs. If any abnormalities are found, mothers-to-be should follow medical advice and seek early treatment. Otherwise, if a miscarriage occurs passively, it will cause greater harm to the mother's body.

2. Systemic Diseases

If pregnant women have acute infectious diseases such as influenza, typhoid fever, pneumonia, bacterial toxins or viruses (such as herpes simplex virus, cytomegalovirus, etc.) can enter the fetal body through the placenta, causing the fetus to stop developing and resulting in miscarriage.

High fever can cause uterine contractions and lead to miscarriage. If pregnant women have severe anemia, heart failure, chronic nephritis, or hypertension, the placental infarction and intrauterine hypoxia can cause fetal malformations, leading to miscarriage. There are also some rare cases, such as when pregnant women have severe illnesses, which can trigger severe malnutrition and make the embryo unable to continue to develop, ultimately leading to miscarriage.


3. Blood Type Incompatibility between Mother and Fetus

If pregnant women have received blood transfusions or have produced incompatible coagulation factors during pregnancy, it will cause aggregation and hemolysis in the fetus, leading to miscarriage.

There are mainly two types of blood type incompatibility between mothers-to-be and fetuses: Rh incompatibility between mother and child: when the mother's blood type is Rh negative and the fetus is Rh positive, once the fetal blood enters the mother's body, the mother will produce antibodies sensitized to the Rh antigen, and these antibodies will enter the fetal blood through the placenta, causing hemolysis, which can cause jaundice, anemia, hepatosplenomegaly, and heart failure in the fetus; ABO blood type incompatibility: when the mother-to-be has blood type O and the fetus has blood type A or B, the mother will produce anti-A or anti-B antibodies in her body, and when blood enters the fetus's body, hemolysis can occur. If any of these symptoms occur, mothers-to-be should go to the hospital for diagnosis and choose medication for treatment in a timely manner.

4. Endocrine Disorders

The fetus mainly absorbs nutrients from the mother's body through the placenta. If the placenta develops poorly or becomes diseased, the fetus will stop growing due to a lack of nutrients, leading to miscarriage.

Endocrine disorders can seriously affect the placenta: insufficient corpus luteum function often affects decidua and placenta, leading to miscarriage; insufficient secretion of pregnancy hormones can cause poor development of the endometrium, affecting the development of the fertilized egg and causing miscarriage; increased prostaglandins can cause frequent contractions of the uterine muscles, leading to miscarriage; hypothyroidism can impair cellular oxidative capacity, thereby affecting the growth and development of the embryo and causing miscarriage.

5. Genetic Defects

If mothers-to-be and fathers-to-be have chromosomal variations, they will be passed on to the baby, and genetic mutations become the main cause of spontaneous miscarriage. The most obvious is miscarriage within the first three months, half of which are caused by chromosomal abnormalities in the embryo, including numerical abnormalities such as trisomy, monosomy, and triploidy; structural abnormalities such as chromosomal breaks, inversions, deletions, or translocations.

Miscarriage becomes the most common outcome for embryos with chromosomal abnormalities, and only a very small number of embryos may continue to develop into babies, but they often have deformities or functional defects after birth.

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