The Lipid-Lowering Effect and Taboos of Ze Xie: A Traditional Chinese Medicine

March 7, 2024

Ze Xie, many people think it is a plant, but it is actually a traditional Chinese medicine. Ze Xie has hepatotoxicity and nephrotoxicity, and its side effects mainly manifest as swelling of the liver and kidneys and other symptoms of poisoning if taken improperly. In addition, Ze Xie contains ze xie alcohol, which can cause decreased appetite and increased bowel sounds. The irritant substance in it can cause gastroenteritis after ingestion.


【The lipid-lowering effect of Ze Xie】

Ze Xie's lipid-soluble part has a significant cholesterol-lowering effect and anti-atherosclerosis effect on experimental hypercholesterolemic rabbits. Ze xie alcohol A, B and ze xie alcohol A, B, C acetates isolated from it all have significant cholesterol-lowering effects, except for ze xie alcohol B.

Adding 0.1% of Ze Xie alcohol A-24-acetate to the feed of rats with experimental hyperlipidemia can reduce blood cholesterol by more than 50%, and the effect is the strongest.

The ethanol extract of Ze Xie, ethanolic macerate ethyl acetate extract, etc., have lipid-lowering effects on experimental hypercholesterolemic rabbits and rats.

【Taboos of Ze Xie】

(1) Cannot be used together with clams and razor clams.

According to the "Compendium of Materia Medica Annotations", Ze Xie is afraid of clams and razor clams. Therefore, the two should not be mixed for use, otherwise it will harm your health and life.

(2) Not suitable for those with kidney deficiency and slippery essence.

"The Famous Physician's Records" said: "Bian Que said, excessive use of patients' eyes." "Introduction to Medicine" says: "For those with frequent urination, thirst, edema, and those caused by kidney deficiency, it should not be used."

"The Annotation of Compendium of Materia Medica" also states: "Patients without dampness and drinking, but with Yin deficiency and exhausted kidney qi, weakened Yang and slippery essence, eye pain, and symptoms such as cold diarrhea, should avoid it."

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