With the continuous understanding of diseases, epidemiologists have realized that simply controlling symptoms during disease outbreaks is far less significant for the long-term prognosis of coronary heart disease than taking preventive measures early on. Musk Cardiotonic Pill has always been known as a "life-saving medicine" used as an emergency treatment for coronary heart disease. However, the clinical value of Musk Cardiotonic Pill is not limited to emergency use, it also plays an important role in secondary prevention.
I: Concept of Secondary Prevention of Coronary Heart Disease
The concept of secondary prevention of coronary heart disease refers to controlling its development and preventing complications in those who already have coronary heart disease, reducing the serious consequences such as death and disability caused by disease progression, promoting better recovery, and thus improving patients' survival rate, reducing the risk of recurrent events, and improving their quality of life. The core pathological change of coronary heart disease is the formation of atherosclerotic plaques in coronary arteries, which leads to vascular lesions and subsequently acute or chronic ischemia in the supplied myocardium. Therefore, no matter what measures are taken for the secondary prevention of coronary heart disease, they are aimed at vascular protection to prevent further development of atherosclerosis and myocardial protection to improve myocardial ischemia. In various coronary heart disease treatment guidelines, whether adopting a healthy lifestyle or using various drugs for treatment, they all start from these two aspects.
II: Long-term Treatment for Protecting Ischemic Myocardium
In 2000, foreign scholars proposed the concept of therapeutic angiogenesis, which aims to promote new blood vessel growth on ischemic myocardium through certain interventions, such as cell factors or receptors that promote angiogenesis, to establish an effective blood supply collateral circulation, achieve restoration of blood supply to ischemic myocardium, and improve patients' symptoms and prognosis. It can also be metaphorically called "medication-induced self-bridging of the heart". In the clinical use of Musk Cardiotonic Pill, it is often found that some patients continue to have improved myocardial blood supply even after a period of discontinuation of the medication, which has sparked research on the promotion of therapeutic angiogenesis by Musk Cardiotonic Pill. Animal experiments using chicken embryo chorioallantoic membrane models, rat myocardial ischemia models, and bovine adrenal microvascular endothelial cells have confirmed the promoting effect of Musk Cardiotonic Pill on therapeutic angiogenesis. At the same time, in humans, through myocardial perfusion imaging using nuclear medicine and other methods, it has been found that long-term use of Musk Cardiotonic Pill in the treatment of coronary heart disease leads to sustained improvement in myocardial ischemia. These all contribute to effective protection of the myocardium.
From the late 1990s to the present, scholars have used many advanced modern research methods such as molecular biology, cell culture, animal models, and nuclear myocardial imaging to study the efficacy and mechanisms of Musk Cardiotonic Pill, and have found that Musk Cardiotonic Pill essentially delays the progression of disease from various aspects of atherosclerosis, providing vascular protection and myocardial protection. The medical community has begun to re-evaluate Musk Cardiotonic Pill and pay attention to its clinical use. A large number of clinical case analyses have shown a significant reduction in the proportion of patients who experience sudden death, myocardial infarction, death, or require surgery or interventional treatment with long-term use of Musk Cardiotonic Pill. This is of great significance in the secondary prevention of coronary heart disease.
III: Long-term Adherence is Necessary for Secondary Prevention
Since the pathological changes of coronary heart disease are a long-term progressive process, the secondary prevention measures for coronary heart disease, whether it is lifestyle adjustments or drug treatment, require long-term adherence. The long-term adherence to secondary prevention measures depends on the difficulty of implementation, the subjective awareness of patients, and the cost involved. For example, adopting a healthy lifestyle can save a lot of medical expenses or even be free, but not all patients can truly adhere to it. The patients' understanding and importance to the disease, as well as the good compliance with treatment drugs, directly affect the long-term prognosis of coronary heart disease. In addition, the high cost of medication is also an important reason why many patients cannot adhere to treatment. Musk Cardiotonic Pill has definite efficacy, high quality, and low price, with a daily treatment cost of only a few yuan, so patients can adhere to long-term use, receiving praise from the medical community and patients, and demonstrating clear advantages in the secondary prevention of coronary heart disease.
IV: Emphasis on Vascular Protection
Protecting vascular endothelium Musk Cardiotonic Pill can protect the vascular endothelium structurally and functionally. Animal experiments have found that after taking Musk Cardiotonic Pill, the drug can increase the level of plasma SOD, enhance the activity of endogenous nitric oxide synthase by upregulating its gene expression, and protect vascular endothelial cells. Observation under electron microscopy reveals intact endothelial cell structure and reduced shedding. In human studies, brachial artery ultrasound was used to detect reactive hyperemic changes in brachial artery diameter, and significant improvement in vascular endothelial function was observed after vascular endothelial function treatment with Musk Cardiotonic Pill.
Reducing lipid infiltration Both animal experiments and human studies have found that Musk Cardiotonic Pill has a certain lipid-lowering effect, reducing total cholesterol, triglycerides, and low-density lipoprotein. After 8 weeks of taking Musk Cardiotonic Pill in a high-fat model of rabbits, the vascular endothelial damage caused by high blood lipids was controlled.
Inhibiting inflammatory response Several independent studies have evaluated the inhibitory effects of Musk Cardiotonic Pill on inflammatory mediators such as matrix metalloproteinases and C-reactive protein, as well as its inhibitory effect on collagen proliferation caused by inflammatory response.
