The Nephrotoxicity of Chinese Herbal Medicine Qingmuxiang: Medicinal Value and Toxicity Analysis

January 3, 2024

Chinese herbal medicine Qingmuxiang is a nephrotoxic medicine. Although it has the effect of promoting Qi circulation and relieving pain, the use of Qingmuxiang in medicine may cause adverse reactions such as kidney damage. Therefore, modern medicine has mostly replaced Qingmuxiang with Guangmuxiang. Let's learn about the medicinal value of Qingmuxiang.


Medicinal Value of Qingmuxiang

In ancient times, Qingmuxiang referred to high-quality Muxiang, also known as Muxiang. The Qingmuxiang we have now was called Tuqingmuxiang during the Tang Dynasty, so this name is not appropriate and has caused a lot of confusion.

The plant of Qingmuxiang is called Tianxianteng, and its fruit is called Madouling. It promotes Qi circulation and relieves pain, but does not have a diuretic effect. It is used for liver and stomach pain, especially for hot diseases. It has detoxifying effects. It has limited significance in treating boils and abscesses and its effects are not strong.

Qingmuxiang decoction has a significant effect in lowering blood pressure caused by various reasons. The Magnolol alkaloids it contains have a significant hypotensive effect on renal hypertension.

Qingmuxiang total alkaloids have different degrees of inhibitory effects on Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus, and other bacteria. It can also enhance the phagocytic function of peritoneal macrophages, indicating an immune-enhancing effect. In addition, this product has anti-cancer, sedative, emetic, and anthelmintic effects.


Toxicity Analysis of Qingmuxiang

The reason why Qingmuxiang is banned is because it has very strong nephrotoxicity. Qingmuxiang contains aristolochic acid, which can cause acute renal failure, acute tubular necrosis, and other serious side effects.

In fact, as early as 2004, it has attracted great attention from the state, and in 2004, the use of "Guangfangji" and the roots of Aristolochiaceae plants, such as Aristolochia and Asarum, which have high content of aristolochic acid, were banned.

In addition, the China Food and Drug Administration officially announced that Chinese medicine preparations containing "Qingmuxiang" have been canceled their medicinal standards due to the possible adverse reactions such as kidney damage. These medicines will be removed from the market.

Nowadays, if Qingmuxiang needs to be used in a prescription, it is replaced by Guangmuxiang. If it must be used, it should be used under the guidance of a qualified physician. The dosage and treatment course should be strictly controlled. During the treatment, the monitoring of renal tubular and glomerular function should be paid attention to. However, it should be used with caution in children and the elderly, and pregnant women, infants, young children, and those with impaired renal function should not take it.

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