The efficacy and effects of Cinchona bark

Wujia Bark was first published in Shennong Ben Cao Jing and is classified as a top quality product. It is the dried root bark of the plant Wujia, family Wujia. Produced in Hubei, Henan Anhui, Sichuan and other provinces. Here we will take a look at the effects and contraindications of Wujia Bark.

Dispersing wind and dispelling cold

It is used to treat wind-cold damp paralysis, pain in the waist and knees, and contracture of the tendons and bones, so it is especially beneficial to the elderly and patients who have been ill for a long time. It can be used for drinking in wine alone, or with angelica, cow's knee, elm and other medicines, such as the "Compendium of Materia Medica" Wu Jia Pi wine. If rheumatism paralysis pain, tendons and veins constricted, flexion and extension unfavorable, can be combined with the efficacy and effects of papaya, pine knot, such as "Shen's Zun Sheng" Wu Jia Pi San.

Removing wind and dampness

For wind-cold dampness congestion in the lower, the two feet bones skin wet swelling pain, with Wu Jia Pi dispel wind and dampness, often with Perilla leaf, Wu Zhu, betel nut, ginger, and also with the efficacy and effects of Yuan Zhi meat for the pill, such as "Rui Zhu Tang experience formula" Wu Jia Pi pill.

Tonifying the liver and kidney, strengthening the muscles and bones

Wu Jia Pi can nourish the liver and kidney and strengthen the muscles and bones. It is used to treat liver and kidney deficiency, soreness and weakness of the waist and knees, impotence of the lower limbs, and delay in children's movement. It is used with Eucommia globulus, Radix et Rhizoma Ginseng, Radix et Rhizoma Bull Knee, etc. It is used in combination with turtle nail, cow knee, papaya and other medicines.

Promoting Blood circulation and regulating menstruation

For women with menstrual blood obstruction, loss of qi and essence, resulting in emaciation, limb fatigue, panting, full of fatigue, fever and sweating, take Wu Jia Pi (nourishing the liver and kidney, strengthening the muscles and bones), can be used with peony skin, angelica, red peony, such as the efficacy and effects of the same, "Taiping Huimin and Pharmaceutical Bureau Formula" oil decoction powder.

Anti-inflammatory

It is believed that the anti-inflammatory effect of Wujia Bark is mainly caused by reducing the release of inflammatory mediators and inhibiting their inflammatory effects. Experiment: The aqueous decoction and n-butanol extract of G. pentaphyllum can significantly inhibit the foot swelling of rats caused by carrageenan gum, and the continuous administration for one week can also significantly inhibit the proliferation of granulation tissue of mouse cotton balls. The alcoholic extract of short-stalked Cinnamomum pentandrae significantly inhibited foot swelling in rats caused by carrageenan, egg white and formaldehyde, and the exudation of tracheoma and proliferation of cotton ball granulation in mice caused by croton oil, and also significantly inhibited adjuvant joint swelling and immune complex-mediated allergic inflammatory reaction in rats.

Reducing immunity

The aqueous decoction and alcoholic precipitation of Cinchona bark had an inhibitory effect on immune function, significantly reduced the phagocytosis percentage and phagocytosis index of mouse abdominal macrophages, and significantly inhibited antibody-forming cells in mouse spleen. The transplantation test of half heart of mice proved that fine column of Wujia Bark had some anti-rejection effect and could significantly prolong the average survival time of transplanted myocardium.

Sedation and analgesia

Pentaphyllum album alcoholic extract exerted a synergistic effect on subthreshold sodium pentobarbital and prolonged the sleep time of mice significantly. Its n-butanol extract and short-stemmed pentagacanth alcohol extract both increased the pain threshold and had significant analgesic effects.

Anti-cadmium mutagenic effect and anti-stress effect

Cadmium is a heavy metal inducer and has a strong mutagenic effect on germ cells, which can induce sperm malformation and increased micronuclei in bone marrow cells in mice. Experiment: Aqueous extract of mice administered by continuous gavage for 5 weeks can reduce cadmium-induced sperm malformation and bone marrow cell micronuclei increase, the inhibition rate was 63.9 % and 74.3 %, respectively. The total saponin of fine column pentosidine significantly prolonged the swimming time, heat stress survival time and normoxia tolerance time in mice.

Promote nucleic acid synthesis

The aqueous alcoholic precipitate of pentosidine increased DNA synthesis in hepatosplenocytes of juvenile mice, and pentosidine polysaccharide promoted DNA synthesis in hepatocytes of CCI4 team mice with toxic liver injury.

Contraindications to the consumption of five plus bark

1, liver and kidney deficiency and fire also contraindicated five plus bark, the lower part of the wind-cold dampness without fire should not be used five plus bark, "Ben Cao Jing Shu": "the lower part of the wind-cold dampness without fire should not be used, liver and kidney deficiency and fire is also contraindicated." The herb is contraindicated for those with deficiency of lung qi and water." 2, for making, Wu Jia Pi fear snake skin, Xuan Shen. The herbal jingji collects notes: "Yuanzhi for making. Fearing snake skin and Xuan Shen."