Effects and contraindications of green bark

Green bark is bitter, pungent, warm, and belongs to the liver, gall bladder, stomach meridian, has the effect of draining the liver and breaking the qi, eliminating stagnation, the following is to see the specific efficacy and effects of green bark contraindications

Diversify the liver

Green bark is bitter, pungent, warming, and penetrating into the liver meridian. It can be used in combination with different herbs to treat liver stagnation, chest pain, hernia pain, and breast paralysis and canker sores.

Eliminating stagnation

Green peel is pungent and bitter, which can not only eliminate stagnation, but also move qi and relieve pain. It is often used in combination with different herbs to treat food stagnation, distension and pain in the abdomen.

Breaking Qi

It can be used in combination with other herbs to treat Qi stagnation, blood stasis, obstruction and lumpiness.

Adjusting the stomach and intestines

Qingpi decoction enhances the peak electrical activity of pylorus, duodenum and jejunum of sheep, shortens the period of small intestine migratory EMG and prolongs the duration of phase III of jejunum migratory EMG, triggers pseudophasic contraction of small intestine, generates migratory motor complex wave, and promotes defecation and urination. Qingpi aqueous decoction enhanced the peak electrical activity of gastric and duodenal smooth muscle in rats. The aqueous decoction of green bark externally inhibited the cardiac contraction activity of rat isolated colon smooth muscle strips, and the inhibitory effect on rat isolated small intestine longitudinal muscle strips was stronger than that of Chenpi. This may be a direct effect on smooth muscle or partially mediated by adrenergic α receptors.

Choleretic

Qingpi injection increases bile elimination in rats and diastens the smooth muscle of guinea pig isolated gallbladder, which counteracts the gallbladder induced by heparanylcholine. Aqueous decoction of green bark was administered intravenously to both normal and carbon tetrachloride liver-injured rats to promote bile secretion, increase bile flow and protect hepatocyte function.

Panting

Intravenous injection of Qingpi alcohol extract in drunken cats counteracted histamine-induced bronchoconstriction and diaped the isolated air of guinea pigs. Green bark injection can resist histamine-induced isolated bronchospastic constriction and reduce histamine-induced reduction in bronchopulmonary perfusion in guinea pigs.

Treatment of shock

Intravenous injection of green bark injection can produce an elevating effect in intoxicated cats, rabbits and rats. Intravenous injection of green bark injection has efficacy on traumatic shock, endotoxic shock, hemorrhagic shock, transfusion shock and anti-pentobarbital sodium toxic shock in acutely anaphylactic shock and histamine-induced shock in guinea pigs and rabbits.

Myocardial contraction

It has a positive effect on the excitability, transmissibility, contractility and autoregulation of the toad's heart muscle, shortening the cardiac cycle, sinus-ventricular excitation conduction time and effective inactivity of the toad's heart in vivo, and strengthening the contractility of the heart.

Anti-thrombotic and platelet aggregation

Qingpi injection has protective effect on focal cerebral blood reperfusion injury in rats by intraperitoneal drip; Qingpi extract has anti-thrombotic effect in vitro; Qingpi aqueous decoction inhibits epinephrine-induced platelet aggregation in vitro.

Other effects

Gavage of green bark aqueous extract in mice or skeletal muscle cells in rats in vitro decreased the energy charge value of skeletal muscle cells. Gavage of green bark aqueous extract in mice with chronic hypoxia-induced energy metabolism disorder also increased oxygen consumption rate, respiratory control rate and creatine kinase activity, and decreased hepatocyte energy charge value. The aqueous decoction of green bark had an inhibitory effect on the smooth muscle strips of isolated rat uterus during the period of artificial estrus, probably by acting on the adrenergic β receptors in the smooth muscle cell membrane. The gavage of different concoctions of B. glauca showed strong and long-lasting analgesic effects after vinegar preparation in mice by twisting method and hot plate method.

Green bark contraindications

1. Cautiously taken by people with qi deficiency. 2. "Renzai Direct Instruction": not to be used if there is sweating. 3. "The Materia Medica Meng Chyuan": Old, weak and deficient people should especially abstain from taking it. 4. "Ben Cao Jing Shu": Do not use if the liver and spleen are deficient.