The efficacy and effects of Crocus sativus

Hooked vine, also known as hooked vine, hanging vine, eagle claw wind, hanging upside down, etc., is a very common Chinese medicine, cool in nature, taste sweet, to the liver, pericardium meridian, the whole plant has medicinal properties, but often use its hooked stems and branches into medicine, has a high medicinal value, so what are the efficacy and effects of hooked vine?

Lowering blood pressure

Its decoction has a blood pressure lowering effect at painful concentrations, and the effect begins 2-7 days after taking the medicine, and is strongest at 10 days, and the whole curve of blood pressure decrease is a slope line, which means that the blood pressure lowering of hooked vine is mild and has minimal side effects on the consumer. Usage: Boil hook vine with water for 10-20 minutes to make a 20% concentration, 20-30 ml each time, 3 times a day.

Sedation

Hookwort contains a plant alkaloids - hookwort alkaloids, hookwort alkaloids belong to indole derivatives, which have specific effects on nerve aspects and can inhibit nerve excitation, this belongs to the common efficacy of indoles, which has been proved in many animal experiments. Mice: Hooked vine decoction 0.1 g/kg was given to mice intraperitoneally, which can produce significant sedative effect. Rats: Hooked vine decoction 1 g/kg given intraperitoneally to rats reduced the excitability of the cerebral cortex. Guinea pig: In the treatment of experimental epilepsy in guinea pigs, the ethanolic infusion of G. hookeri stopped the occurrence of epileptic reactions after 3-8 days, and restored the pre-treatment state 3 days after discontinuation of the drug.

Inhibition of uterine contractions

The contraction of the uterus is regulated by the smooth muscle in the uterus, and the contraction of the smooth muscle requires calcium ions to stimulate the contractile proteins to achieve, and the alkaline component contained in hookwort has the effect of blocking the calcium ion channel and inhibiting the inward flow of calcium ions, and the higher the concentration the stronger the inhibition, which has a strong effect of inhibiting the contraction of the uterus.

Regulation of heart rate

Crotaline slows the spontaneous rhythm of guinea pig isolated atria, inhibits the contractility of atria, and is not blocked by atropine. It can non-competitively antagonize the positive chronotropic effect of isoproterenol, and its negative chronotropic and force-changing effects, which may be related to the inhibition of cardiomyocyte membrane calcium transport. May prevent and treat cardiac arrhythmias.

Anticoagulation

Crotaline can significantly inhibit arachidonic acid, collagen and ADP-induced platelet aggregation in rats, and has a significant depolymerizing effect on ADP-induced platelet aggregation in rabbits. Crotaline can also improve the deformability of red blood cells and can prevent thrombus formation.

Contraindications of hookwort

Hooked vine has the effect of inhibiting neural excitation, can be a kind of treatment of epilepsy Chinese medicine, but the dose needs to be strictly controlled, hooked vine treatment of epilepsy is very close to the effective dose and toxic dose, in the consumption of too much will cause poisoning. The effective dose and the toxic dose of hooked vine for epilepsy are close to each other, and too much consumption can cause poisoning. 2. Hooked vine is not toxic at low doses, but at high doses it will show toxic damage to the heart, liver and kidneys. Therefore, it is important to conduct regular liver and kidney function tests when consuming Crotaline for treatment.