Efficacy and effects of chuanxiong and contraindications

Chuanxiong is a herbal plant commonly used to invigorate blood circulation, dispel wind and relieve pain. It is suitable for various diseases caused by stasis of blood. Here we will look at the efficacy and contraindications of Chuanxiong.

Pungent, dispersing, warming and promoting circulation, activating blood circulation and removing blood stasis

Chuanxiong Ligusticum is a pungent, warming and generalizing herb that activates blood circulation and dispels blood stasis. It is widely used for pain in the chest, rheumatism and paralysis, obstruction of the masses, sores and swelling, painful bruises, irregular menstruation, menorrhagia and dysmenorrhea, postpartum stasis and pain.

Pungent and good at ascending

Chuanxiong Ligusticum is pungent and good at ascending, and can go up to the top of the head and eyes, with the effect of dispelling wind and relieving pain, and is an important medicine for treating headache and wind, and is used for cold and headache and migraine.

Regulating the nervous system

Chuanxiong has obvious sedative effects. The volatile oil of Rhizoma Ligusticum Chuanxiong has an inhibitory effect on the activity of the brain of animals in small amounts, while it has an excitatory effect on the respiratory center of the delayed brain, the vasomotor center and the reflex center of the spinal cord.

Enhances blood flow

Studies have found that chuanxiong has an enhancing effect on blood flow, resulting in increased heart rate, enhanced myocardial contractility and vasodilation in animals, and these effects increase with dose. Moreover, Chuanxiong has a very obvious effect against Pit-induced acute myocardial ischemia and hypoxia.

Stimulation of uterine contraction

A 10% aqueous solution of Chuanxiong Ligusticum infusion on the isolated uterus of pregnant rabbits stimulates the pregnant uterus in minute amounts, causing it to increase in tension and contraction, eventually becoming a contracture; in large amounts, it in turn paralyzes the uterus and the contraction stops.

Inhibit pulmonary vasoconstriction

Chuanxiongzin can also inhibit pulmonary vasoconstriction caused by hypoxia, and has an inhibitory effect on vasoconstriction caused by adrenaline or barium chloride.

Anti-spasmodic

The ferulic acid and neutral components contained in chuanxiong have antispasmodic effects on smooth muscle. Chuanxiong alkaloids, ferulic acid and chuanxiong lactone all have antispasmodic effects, while ligustilide is the main antispasmodic component. iv Ligustilide also significantly relieves spasmodic contractions of tracheal smooth muscle caused by acetylcholine, histamine and barium chloride.

Inhibition of pulmonary vasoconstriction

In addition to inhibiting hypoxia-induced pulmonary vasoconstriction, chuanxiongzin also inhibits epinephrine- or barium chloride-induced vasoconstriction. The mechanism of action of Chuanxiongzin from isolated tissues and cells suggests that the relaxing effect of Chuanxiongzin on aortic smooth muscle is very similar to the properties of isoparasitic arrest, and it is speculated that Chuanxiongzin may be a new calcium antagonist.

Antibacterial effects and other in vitro tests

Ligusticum chuanxiong has inhibitory effects on colorectal, dysentery (Sone's), metaplasia, green pus, typhoid, S. paratyphi and Vibrio cholerae. Rhizoma Chuanxiong aqueous infusion (1:3) also inhibited certain pathogenic skin fungi in test tubes.

Anti-radiation

Decoction of Chuanxiong Ligusticum has been effective in the experimental treatment of radiation sickness in animals. The water-soluble crude preparation of Chuanxiong Ligusticum has a protective effect against radiation exposure and nitrogen mustard injury in rats, mice and dogs. The anti-radiation effect of Chuanxiong is better in rats than mice, ip is more effective than im administration, and im administration is more effective than ig.

Other effects

Chuanxiong Ligusticum inhibits DNA synthesis, suggesting that it can inhibit protein and antibody production. Chuanxiong has some anti-vitamin E deficiency effects, and it protects chicks from nutritional encephalopathy caused by vitamin E deficiency. Chuanxiongzin increased renal blood flow in anesthetized rabbits and was diuretic. Chuanxiong Xiongzin inhibited the development of pulmonary fibrosis in mice prepared by intratracheal administration of pinyamycin.

Contraindications of Chuanxiong

1, Yin deficiency and fire, the upper Shengxia and Qi weak people should not be taken. Because in the "Classic of the Materia Medica" mentioned: where the patient on the Shengxia deficiency, deficiency fire inflammation, vomiting and cough, spontaneous sweating, night sweating, dry throat and mouth, fever as thirst irritability, the law and contraindicated. 3, "get with the materia medica": fire drama in the full, spleen deficiency food less, fire headache are prohibited. 4. "Essence of Pinhui": Long-term use will disperse the true qi. Therefore, Chuanxiong should not be taken for a long time. 5、The Materia Medica Meng Chyuan：Evil Astragalus, Cornu and Wolfsbane. Fears saltpeter, slippery stone, and yellow lily. Against quinoa. 6, "the herb from the new": gas rose phlegm asthma should not be used.